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promyelocytic (M3) acute leukaemia; a number of patients Specific an strange morphologic spectrum intermediate in between M2 and M3 AML.
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large level of typical or dystrophic promyelocytes in peripheralblood As well as in bone marrow; no intracytoplasmic Auer rods; myeloperoxydasereaction optimistic; immunocytochemical detection having an anti-PLZF exhibits adistinct punctate nuclear distribution with the protein, suggesting itscompartmentalization within the nucleus.
Swift detection of prognostically substantial fusion transcripts in acute leukemia working with simplified multiplex reverse transcription polymerase chain response.
ZBTB16-RARα variant of acute promyelocytic leukemia with tuberculosis: a scenario report and evaluate of literature.
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Prosperous allogeneic bone marrow transplantation inside of a case of variant acute promyelocytic leukemia with ZBTB16-RARA.
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A situation of acute promyelocytic leukaemia with abnormal cytological characteristics plus a ZBTB16-RARA fusion gene.
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Characterization of cryptic rearrangements and variant translocations in acute promyelocytic leukemia.
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the translocation involves a breakpoint during the zinc fingerregion of PLZF, with fusion of two zinc fingers to your RARa B region toform a five PLZF - 3 RARa fusion gene; the reciprocal five RARa - 3 PLZF genefuses 7 zinc fingers on the RARa region; RARas breakpoint takes place in1- because of thealternative splicing of PLZF gene, two forms of PLZF-RARa protein is often detected:
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